On this page you will find a collection of active addiction-related projects ongoing across Rutgers. Learn about on-going research projects and datasets available for analysis. Contact information for each project listed below is provided.

If you are interested in hosting your project on this page, please email rarc@bhi.rutgers.edu with your project details.

  • Collaborative Studies on the Genetics of Alcoholism (COGA)

    The Collaborative Study on the Genetics of Alcoholism (COGA) is a multi-site project whose goal is to identify specific genes involved in the predisposition to alcohol dependence and related disorders. The COGA sample consists of large families densely affected with alcohol dependence, who were identified through inpatient or outpatient alcohol treatment programs. All individuals were administered the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) interview, a polydiagnostic instrument that assesses most major psychiatric disorders. Since 1991, COGA has interviewed more than 17,000 members of more than 2,200 families from across the United States, many of whom have been longitudinally assessed. COGA has used a variety of complementary strategies for gene identification, and has a variety of genotyped samples in which different types of genetic analyses are on-going. These include (1) family-based linkage sample; (2) case control GWAS sample; and (3) child-adolescent sample. Family members, including adults, children, and adolescents, have been carefully characterized across a variety of domains, including alcohol and other substance-related phenotypes, co-occurring disorders (e.g. depression), electrophysiology, key precursor behavioral phenotypes (e.g. conduct disorder), and environmental risk factors (e.g. stress). COGA participants have also provided a blood sample that has been used to create a repository of DNA and cell lines which are used for genetic studies.

    To inquire about data access, email Dr. Danielle Dick (Danielle.m.dick@rutgers.edu) and Dr. Jessica Salvatore, jessica.salvatore@rutgers.edu.

  • The College Pile Up study

    The College Pile Up study is a two-year study that seeks to understand how typical college health behaviors, such as drinking alcohol and experiencing high levels of stress, affect the cardiovascular system. The study includes 2 in-person laboratory sessions and weekly online surveys for 4 semesters. In the lab, cardiovascular reactions to several breathing tasks are assessed. Online surveys assess substance use, exercise, sleep, and stress. This rich longitudinal dataset will be used to better capture facets of substance use patterns and how they overlap with other common health behaviors, such as high stress and insufficient sleep.

    If you are interested in working with this dataset, please contact Dr. Jennifer Buckman, jbuckman@rutgers.edu.

  • Compound RUEC2-118 a fast-acting treatment for general anxiety and panic disorder

    We are involved in collaborative proof-of-concept studies of compound RUEC2-118, a novel partial GABAAR positive modulator, as a fast-acting treatment for general anxiety and panic disorder, to prevent benzodiazepine withdrawal and overdose fatalities.

    To inquire about this project, please contact Dr. Jacques Roberge, jr1257@rutgers.edu.

  • Cultural and Environmental Influences on Precursors to and Early Stages of Alcohol, Nicotine, and Cannabis Use in Black and Latinx Youth

    Reducing harms associated with early and problem use of alcohol, nicotine, and cannabis among Black and Latinx youth requires insight into the family and community level cultural and environmental factors most salient to substance use risk in Black and Latinx girls and boys from the pre- to mid-adolescent years. The proposed secondary data analysis project focuses on cultural and environmental factors of particular relevance to members of racial/ethnic minority groups, such as racial/ethnic discrimination and ethnic identity, as well as those more prevalent in Black and Latinx than White youth (e.g., neighborhood disadvantage, religious involvement) to characterize pathways of substance use – from cognitions that precede first use to early onset regular use – from ages 9 to 16. Findings will lay the groundwork for cultural tailoring of substance use prevention strategies for Black and Latinx youth toward the broader goal of reducing substance use related health disparities.

    To inquire about this project, please email Dr. Carolyn Sartor, csartor@ifh.rutgers.edu

  • Development of genetically encoded fluorescent reporters for in vitro study

    Extracellular DA levels are influenced by two important presynaptic proteins: the DA D2 receptor short isoform (D2DRsh), which acts presynaptically as an inhibitory autoreceptor; and the DA transporter, DAT, which clears extracellular DA through reuptake. D2DRshs and DATs are internalized, and portions are recycled back onto the cell membrane. To better understand these trafficking events in drug addiction, we are in the process of engineering and optimizing genetically encoded fluorescent reporters with biophysical properties suitable for reporting membrane trafficking of DAT and D2DRsh in vivo. We have made prototypes for in vitro study and we welcome collaborations.

    If you are interested in getting involved, please contact Dr. Pingyue Pan, pingyue.pan@rutgers.edu.

  • Ecological Momentary Assessment of Racial Microaggressions and Alcohol Use in African American Young Adults

    African American adults are disproportionately exposed to alcohol-related risk factors and experience high levels of alcohol-related illness, injuries, and negative social consequences, making the identification of prevention and intervention targets for this population a crucial public health aim. Racial discrimination has been linked to problem drinking among African Americans, but the impact of everyday race-related discriminatory events, known as racial microaggressions, and possible buffers against their effects on day-to- day drinking behaviors have yet to be identified. The submitted project implements an ecological momentary assessment (EMA) to track race-related microaggression experiences and drinking behaviors in real time among African American adults in the peak period of risk for problem drinking (ages 18-25) to evaluate associations between racial microaggressions and alcohol use in this high-risk group.

    To inquire about this project, please email Dr. Carolyn Sartor, csartor@ifh.rutgers.edu

  • Effectiveness of the Opioid Overdose Recovery Program on treatment linkage and repeat overdose

    NJ has developed the Opioid Overdose Recovery Program (OORP), which provides peer-to-peer recovery supports and linkage to treatment for opiate overdose survivors identified in hospital emergency departments. We will evaluate the effectiveness of the OORP on treatment linkage and repeat overdose using Medicaid data. Our design calls for two approaches to assessing OORP effectiveness.  These include: 1) a comparison of outcomes of all patients treated for non-fatal overdose in OORP (intervention group) and non-OORP (control group) hospitals before and after OORP implementation (intention-to-treat, or ITT, analysis); and 2) a comparison of the outcomes of Medicaid-eligible individuals enrolled in the OORP program (the intervention group) with a randomly-selected matched group of patients seen at non-OORP hospitals (the control group) during the same time frame (as-treated analysis).

    To inquire about the project, contact Dr. Nina Cooperman, Psy.D., cooperna@rwjms.rutgers.edu.

  • Enhancement and Expansion of the C3I Program to develop tobacco cessation treatment capacity and infrastructure for cancer patients

    The goal of this project is to improve tobacco treatment at comprehensive cancer centers.

    To inquire about this project, please contact Dr. Michael Steinberg, steinbmb@rutgers.edu (P30CA072720; PI Libutti).

  • Evaluating Cigarette Relighting Behavior: Prevalence, Correlates, Toxicant Exposure, and Implications for Cessation

    The goals of this study are to: 1) describe the prevalence, frequency of, and reasons for cigarette relighting behaviors among smokers, 2) characterize effects of relighting on smoke toxicant deliveries and subjective smoking measures, and 3) investigate the potential impact of relighting on tobacco treatment delivery and cessation.

    To inquire about this project, please contact Dr. Michael Steinberg, steinbmb@rutgers.edu (R01CA260831-01-A1; MPI Steinberg, M.B./Heckman, C./Stepanov, I.).

  • FELONY WOMEN

    FELONY WOMEN is a multi-site and multi-temporal ethnography of women in conflict with the law. Using an interdisciplinary feminist theoretical framework focusing on critical and feminist criminology with other feminist approaches in geography and health, the research has one overall purpose: to reveal how women in conflict with the law make meaning of their lives across time and place through systems and experiences of oppression and resistance. The research returns to the same group of women more than a decade after my ethnography of their incarceration and reentry in a correctional halfway house. It weaves together women’s pathways to drugs and crime, their incarceration experience, and post imprisonment life to show how patterns of harm and the ways women cope are revealed across the lifetime in all spheres of life. It positions women as agents of change and details interconnections of the women’s identity markers such as race, ethnicity, gender, sexuality, and age.

    For more information, contact Dr. Gail Caputo, gcaputo@rutgers.edu.

  • The Finnish Twin Studies

    FinnTwin16 (FT16) and FinnTwin12 (FT12) are two population-based twin studies aimed at understanding how genetic and environmental influences impact the development of alcohol use and related behaviors across adolescence and into young adulthood. All twins were identified through Finland’s Central Population Registry, permitting exhaustive and unbiased ascertainment of all twins born in the country across 10 birth, for a total of ~10,000 twins and their families. FT16 has questionnaire assessments at ages 16, 17, 18.5, and in the mid-20s. These questionnaires contain items on alcohol use, smoking, other drug use, personality, and related health habits and environmental factors. A subset of the twins highly concordant or discordant for alcohol use in adolescence (~600 twins) also completed psychiatric interviews, DNA collection, electrophysiological measures, and neuropsychological testing at the mid-20s assessment. FT12 first assessed children at age 12, with follow-ups at age 14, 17, and in the young 20s. FT12 contains rich data from the twins, parents, teachers, and peers. A subset (~1850 twins and their parents) also completed psychiatric interviews at ages 14 and 22. GWAS data for this subset are also available.

    To inquire about data access, email Dr. Danielle Dick, danielle.m.dick@rutgers.edu and Dr. Jessica Salvatore, jessica.salvatore@rutgers.edu.

  • Genetic predisposition to cocaine addiction

    This project aims to understand the role of a Parkinson’s disease gene, PARK20/SYNJ1, in regulating cocaine tolerance in mice. Through collaboration with Drs. David Barker and Ron Hart, we investigate by using imaging, bioinformatics and behavioral analyses.

    To inquire about this project, please contact Dr. Pingyue Pan, pingyue.pan@rutgers.edu.